Detailed view for Smp_134860

Basic information

TDR Targets ID: 292798
Schistosoma mansoni, translational activator gcn1-related
Source Database / ID:  GeneDB

pI: 6.3406 | Length (AA): 2916 | MW (Da): 327579 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02985   HEAT repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0033674   positive regulation of kinase activity  
GO:0033554   cellular response to stress  
GO:0019901   protein kinase binding  
GO:0006417   regulation of translation  
GO:0043022   ribosome binding  
GO:0019887   protein kinase regulator activity  
GO:0005515   protein binding  
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 16 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
74 1086 4hat (C) 21 1024 10.00 0 0.84 0.308594 0.6
512 1395 2x19 (B) 27 942 11.00 0 0.93 0.332355 0.18
936 1725 4xrk (A) 67 857 11.00 0 1 0.318119 0.25
995 1852 3w3z (A) 51 980 14.00 0 1 0.378439 0.32
1088 2018 5vch (A) 41 1098 14.00 0 1 0.338473 0.07
1198 2276 1u6g (C) 10 1197 16.00 0 1 0.417227 0.39
1419 1568 5nr4 (A) 47 195 23.00 0.71 0.99 0.43954 -1.05
1461 1846 6hwp (A) 54 373 34.00 0.0017 1 0.188473 0.58
1526 2311 1z3h (B) 108 929 14.00 0 1 0.256747 0.59
1540 1687 3sl9 (A) 150 304 13.00 0 0.25 0.204954 -1.2
1614 2384 4c0q (B) 6 873 12.00 0 0.81 0.205603 0.86
1739 2711 5hdt (A) 114 1089 14.00 0 1 0.388876 0.44
1872 2791 1wa5 (C) 22 957 12.00 0 1 0.342701 0.43
2237 2296 5chl (A) 12 71 15.00 0 0 0.126776 -0.3
2751 2896 5mfo (A) 60 208 8.00 0.5 0.07 0.164069 -1.11
2774 2914 4rzp (A) 74 221 15.00 0.63 0.67 0.267354 -1.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128125)

Species Accession Gene Product
Arabidopsis thaliana AT1G64790   protein ILITYHIA
Babesia bovis BBOV_II003920   HEAT repeat family protein
Brugia malayi Bm1_44525   HsGCN1
Candida albicans CaO19.5328   N terminus is frameshifted into CaP19.5333 upstream
Candida albicans CaO19.12793   similar to N terminus of S. cerevisiae GCN1 (YGL195W) translational activator of GCN4 via activation of eIF2alpha kinase GCN2 in
Candida albicans CaO19.12788   N terminus is frameshifted into CaP19.12793 upstream
Candida albicans CaO19.5333   similar to N terminus of S. cerevisiae GCN1 (YGL195W) translational activator of GCN4 via activation of eIF2alpha kinase GCN2 in
Caenorhabditis elegans CELE_Y48G9A.3   Protein GCN-1
Cryptosporidium hominis Chro.80225   hypothetical protein
Cryptosporidium parvum cgd8_1930   large protein with a GCN1 domain
Dictyostelium discoideum DDB_G0279487   GCN1-like protein
Drosophila melanogaster Dmel_CG17514   CG17514 gene product from transcript CG17514-RA
Echinococcus granulosus EgrG_000967600   translational activator gcn1
Entamoeba histolytica EHI_078260   HEAT repeat domain containing protein
Echinococcus multilocularis EmuJ_000967600   translational activator gcn1
Homo sapiens ENSG00000089154   GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
Leishmania braziliensis LbrM.18.0910   hypothetical protein, conserved
Leishmania donovani LdBPK_180820.1   hypothetical protein, conserved
Leishmania infantum LinJ.18.0820   hypothetical protein, conserved
Leishmania major LmjF.18.0820   hypothetical protein, conserved
Leishmania mexicana LmxM.18.0820   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_02023   hypothetical protein
Mus musculus ENSMUSG00000041638   GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
Neospora caninum NCLIV_031730   translational activator, putative
Oryza sativa 4333935   Os03g0721200
Saccharomyces cerevisiae YGL195W   Gcn1p
Schistosoma japonicum Sjp_0111150   expressed protein
Schistosoma japonicum Sjp_0124290   IPR000357,HEAT,domain-containing
Schistosoma japonicum Sjp_0007570   Translational activator GCN1, putative
Schistosoma mansoni Smp_134860   translational activator gcn1-related
Schistosoma mansoni Smp_075950   hypothetical protein
Schmidtea mediterranea mk4.006229.01   Translational activator GCN1
Schmidtea mediterranea mk4.006229.00   Translational activator GCN1
Schmidtea mediterranea mk4.012988.00  
Trypanosoma brucei gambiense Tbg972.10.16050   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.13280   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_10_11380   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_10_11370   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508891.130   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.503681.9   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506357.130   hypothetical protein, conserved
Toxoplasma gondii TGME49_231480   GCN1, putative
Trichomonas vaginalis TVAG_458760   translational activator gcn1, putative
Trichomonas vaginalis TVAG_417700   translational activator gcn1, putative

Essentiality

Smp_134860 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.13280 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.13280 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.13280 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.13280 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_231480 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_134860 (Schistosoma mansoni), translational activator gcn1-related
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